John W. Huffman

1932–2022 · American · Clemson University (1960–2010)

Made over 400 synthetic cannabinoids to probe the CB1 and CB2 receptors, publishing each structure openly. JWH-018 and its siblings were lifted from those papers and sprayed onto herbal blends sold as "Spice" and "K2". Huffman was unambiguous about it: "It bothers me that people are so stupid as to use this stuff."

Compounds credited overall: 400+ synthetic cannabinoids

On this site

• Cannabinoids
• JWH-018 C24H23NO first synthesis

  Published as a CB1/CB2 research tool; taken up as a "Spice" additive from the published route.

Sources

• https://en.wikipedia.org/wiki/John_W._Huffman