CH₃CH₃

JWH-081

Chemistry

53 atoms · Conformer computed and published by PubChem.
Formula
C25H25NO2
Molar mass
371.5 g/mol
IUPAC name
(4-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
InChIKey
UBMPKJKGUQDHRM-UHFFFAOYSA-N

Chemistry from PubChem CID 10547208.

Also known as

  • 210179-46-7
  • JWH 081
  • DEA No. 7081
  • 77E58024IT
  • J980.247I
  • DTXSID80175225
  • RefChem:150675
  • DTXCID8097716

Attribution

  • John W. Huffman — first synthesis, 2005

    1-Pentyl-3-(4-methoxy-1-naphthoyl)indole; Ki 1.2 nM at CB1 vs 12.4 nM at CB2, about tenfold CB1-selective. Sources disagree on which paper introduced it — the Wikipedia Ki table cites Aung et al. (Drug Alcohol Depend. 2000) while the article body cites Huffman et al. (Bioorg. Med. Chem. 2003 and 2005). The 2005 paper is the one whose stated scope covers 4-methoxy naphthoyl substituents, so that year is used here.

    source

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