CH₃CH₃

JWH-015

Chemistry

46 atoms · Conformer computed and published by PubChem.
Formula
C23H21NO
Molar mass
327.4 g/mol
IUPAC name
(2-methyl-1-propylindol-3-yl)-naphthalen-1-ylmethanone
InChIKey
LJSBBBWQTLXQEN-UHFFFAOYSA-N

Chemistry from PubChem CID 4273754.

Also known as

  • 155471-08-2
  • JWH 015
  • JWH015
  • (2-methyl-1-propylindol-3-yl)-naphthalen-1-ylmethanone
  • DTXSID60165902
  • RefChem:792600
  • DTXCID4088393
  • (2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

Attribution

  • John W. Huffman — first synthesis, 1994

    1-Propyl-2-methyl-3-(1-naphthoyl)indole, from Huffman, Dai, Martin and Compton, 'Design, synthesis and pharmacology of cannabimimetic indoles' (Bioorg. Med. Chem. Lett. 4:563–566, 1994) — the paper that started the indole series by replacing WIN 55,212-2's aminoalkyl group with a plain alkyl chain. Ki 164 nM CB1 vs 13.8 nM CB2; one of the first compounds with genuinely useful CB2 selectivity, and still a standard laboratory CB2 agonist.

    source

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