JWH-057

Chemistry

Also known as

• 1-Deoxy-delta(8)-THC DMH
• 8I28LF0B2D
• 105823-04-9
• 1',2'-Dimethylheptyl-1-deoxy-delta(8)-tetrahydrocannabinol
• 1-Deoxy-delta(8)-1',2'-dimethylheptyltetrahydrocannabinol
• RefChem:906244
• (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran
• CHEMBL57723

Stereoisomers

2 distinct stereoisomers are registered for this structure.

• (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo(b,d)pyran this area CID 129128
• (6aS,10aS)-6,6,9-trimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene CID 156683018

Attribution

• JW

  John W. Huffman — first synthesis, 1996

  1-Deoxy analogue of Δ8-THC with high affinity at both receptors (Ki 23 nM CB1, 2.9 nM CB2). Grouped with JWH-051 in the 1996 deoxy-cannabinoid work; the compound-level year rests on the Huffman-series Ki table rather than an abstract that names the code.

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