JWH-051

Chemistry

65 atoms · Conformer computed and published by PubChem.

Formula: C25H38O2
Molar mass: 370.6 g/mol
IUPAC name: [(6aR,10aR)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methanol
InChIKey: ORTVDISIJXKUAV-FCHUYYIVSA-N

Deoxy-HU210
CHEMBL1277685
SCHEMBL12632439
SCHEMBL31611112
DTXSID001027455
BDBM50330773
Q6109180
((6aR,10aR)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-9-yl)methanol

3 distinct stereoisomers are registered for this structure.

Deoxy-HU210 this area CID 9799540
[(6aS,10aS)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methanol CID 60084387
[(6aR,10aS)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methanol CID 160079754
[6,6-Dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-9-yl]methanol mixture CID 72643882

John W. Huffman — first synthesis, 1996
A 1-deoxy-11-hydroxy-Δ8-THC dimethylheptyl analogue — a 'classical' dibenzopyran rather than an indole — from Huffman, Yu, Showalter et al., 'Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor' (J. Med. Chem. 39:3875–3877, 1996). Showed the phenolic hydroxyl of THC is not required for receptor binding, and was one of the first CB2-preferring ligands.

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