Subjects

Opioids Anything acting at the μ/κ/δ opioid receptors — natural, semi-synthetic and fully synthetic. 10 families 112 molecules 1 chemist 20 posts · active 6d ago

Depressants Sedative-hypnotics. Mostly GABAergic, and the class where cross-tolerance and additive respiratory depression kill. 11 families 84 molecules 1 chemist 16 posts · active 4d ago

Dissociatives NMDA antagonism and dissociative anaesthesia. 4 families 31 molecules 1 chemist 15 posts · active 6d ago

Psychedelics Classical serotonergic psychedelics — 5-HT2A agonists. Salvia is NOT here: it has no 5-HT2A activity. 6 families 128 molecules 5 chemists 22 posts · active 6d ago

Entactogens Empathogens. Serotonin releasers — mechanistically distinct from both stimulants and psychedelics. 3 families 30 molecules 5 chemists 8 posts

Stimulants CNS activation — dopaminergic and noradrenergic. 10 families 70 molecules 3 chemists 7 posts · active 6d ago

Cannabinoids CB1/CB2 ligands — plant, endogenous and synthetic. 4 families 110 molecules 6 chemists 2 posts

Antidepressants Chronic-dosing mood agents. Listed for interaction safety — serotonin syndrome lives here. 5 families 29 molecules 2 chemists

Antipsychotics Dopamine antagonists and partial agonists. 2 families 16 molecules 1 chemist

Deliriants Antimuscarinic delirium — true hallucination, not psychedelia. 2 families 6 molecules

Nootropics Cognitive enhancement, of varying evidence quality. 4 families 21 molecules

Anabolics & Hormones Performance, physique and metabolic agents. 5 families 30 molecules

Misc Genuinely unclassified, or too new to place. Should stay small — if it grows, a family is missing. 7 sections

Atypical Substances whose mechanism has no populated neighbours. A real home, not a junk drawer — each family here is mechanistically distinct. 7 families 33 molecules 1 chemist 2 posts · active 6d ago

Other Pharmaceuticals Medical agents without a primary recreational class, kept so interactions and tapers have somewhere to live. 9 families 49 molecules 1 chemist

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