Psychedelics

Membership here is decided by mechanism, not by structure: everything in this subject agonises the 5-HT2A receptor, and blocking that receptor stops the experience. The scaffolds underneath are unrelated to each other — lysergamides, tryptamines, phenethylamines, the N-benzyl series, benzodifurans and β-carbolines — and little transfers between them. Potency, onset, duration and whatever else a compound touches vary enormously from one family to the next, so a dose or a timeline learned from one says nothing about another.

Salvia is NOT here: salvinorin A is a selective κ-opioid agonist with no 5-HT2A activity, and it is filed under Atypical, as are muscimol and Amanita muscaria. What hurts people in this class is rarely simple toxicity. The NBOMe family's margin is far narrower than the blotter it is sold as, several members are strong vasoconstrictors, and the β-carbolines filed here are MAO inhibitors — so the serotonergic interactions live inside the subject as well as outside it.