Escaline

Chemistry

35 atoms · Conformer computed and published by PubChem.

Formula: C12H19NO3
Molar mass: 225.28 g/mol
IUPAC name: 2-(4-ethoxy-3,5-dimethoxyphenyl)ethanamine
InChIKey: RHOGRSKNWDNCDN-UHFFFAOYSA-N

Chemistry from PubChem CID 38240.

Also known as

39201-82-6
4-Ethoxy-3,5-dimethoxybenzeneethanamine
Q13F1C1N8I
ETHYLAMINE, 3,5-DIMETHOXY-4-ETHOXYPHENYL-
RefChem:1070585
2-(4-ethoxy-3,5-dimethoxyphenyl)ethanamine
Benzeneethanamine, 4-ethoxy-3,5-dimethoxy-
3,5-Dimethoxy-4 ethoxyphenylethylamine

Attribution

David E. Nichols — discovered its activity, 1977
NOT a Nichols first synthesis — escaline was described by George S. Grace in 1934 and again by Benington and colleagues in 1954. Nichols and Dyer prepared the 4-alkoxy mescaline homologue series (escaline, proscaline, isoproscaline) and showed serotonin-agonist potency tracks lipophilicity. The Wikipedia biography's phrasing on this point is misleading.

source
Alexander "Sasha" Shulgin — popularised it, 1991
NOT his synthesis: first described by George S. Grace in 1934, later made by Benington (1954), Leminger (1972) and Nichols (1977). Shulgin's PiHKAL entry (#72) supplies the human dosage data the field relies on.

source

General Open discussion — anything that fits nowhere narrower. no posts yet Legal Scheduling status, pending actions, and where the law actually stands. no posts yet Dosage Dose ranges by route, and the margins between them. no posts yet Experiences First-hand reports — set, setting, and what actually happened. no posts yet Chemistry Structure, synthesis, and analytical chemistry. no posts yet Interactions Combination risks — what must not be mixed, and why. no posts yet

Hot Top New Active

sign in to post

No posts here yet.