Introduced by Huang, Marona-Lewicka and Nichols as 'a potent new non-neurotoxic serotonin-releasing agent' — a laboratory probe for the serotonin transporter, never intended for human use. It appeared on the European street market around 1997–98 as 'flatliners' and was implicated in several deaths; Nichols has written about this publicly. Marked medium because the 1992 paper does not explicitly claim first synthesis and earlier literature on p-methylthioamphetamine could not be ruled out.
