LSA (Ergine): general

LSA, also called ergine, is a naturally occurring psychedelic of the lysergamide and ergoline families, related to LSD [1][2]. It's the main psychoactive alkaloid in the seeds of morning glory and related Convolvulaceae plants — including Rivea corymbosa, Argyreia nervosa, and Ipomoea tricolor — and is generally taken as a preparation made from those seeds [3][2][4]. It was first isolated from ergot in 1932, and Albert Hofmann tested it in humans in 1947 [1].

Reported effects include euphoria and hallucinations, but also nausea and anxiety, and these can come together in the same experience [3]. Some evidence points to a possible therapeutic use for cluster headaches, but this is not the same as knowing how to dose it safely for recreational use [3].

Dosing with LSA is inconsistent, and there's a lot of misinformation circulating about it online — both of these heighten the risks of using it [3]. If you're using it: start with a fraction of what you think you need, wait it out fully before considering more, and don't combine it with other substances or use it alone.

As with psychedelics generally, drug checking services may assist in identifying impurities in a sample [5].

References

1. Ergine — Wikipedia
2. LSA - PsychonautWiki — PsychonautWiki
3. Lysergic Acid Amide (LSA), an LSD Analog: Systematic Review of Pharmacological Effects, Adverse Outcomes, and Therapeutic Potentials. — Europe PMC
4. Ergine — ChemEurope
5. Harm reduction practises for users of psychedelic drugs: a scoping review — Harm Reduction Journal