Ketoconazole

Chemistry

Also known as

• Nizoral
• 65277-42-1
• Panfungol
• Ketoderm
• Fungarest
• Fungoral
• Ketoisdin
• Ketozole

Stereoisomers

4 distinct stereoisomers are registered for this structure.

• Ketoconazole this area CID 47576
• (2R,4S)-Ketoconazole CID 456201
• (2S,4S)-ketoconazole CID 638701
• trans-Ketoconazole CID 12854713
• 1-(4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone mixture CID 3823

Attribution

• PJ

  Paul Janssen — first synthesis, 1976

  Janssen Pharmaceutica under his direction only — the chemistry paper (J Med Chem 1979) is Jan Heeres, Leo Backx, J.H. Mostmans and Jan Van Cutsem, without Janssen as an author. The first orally active broad-spectrum antifungal; patented 1977, US introduction 1981. Family name is invented.

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