Loperamide

Chemistry

67 atoms · Conformer computed and published by PubChem.

Formula: C29H33ClN2O2
Molar mass: 477.0 g/mol
IUPAC name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
InChIKey: RDOIQAHITMMDAJ-UHFFFAOYSA-N

Chemistry from PubChem CID 3955.

Also known as

53179-11-6
Loperamida
Loperamidum
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
Fortasec
DTXSID6045165
6X9OC3H4II
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-N,N-dimethyl-2,2-diphenylbutanamide

Attribution

Paul Janssen — first synthesis, 1969
Credited to Janssen personally in 1969; the published chemistry (J Med Chem 1973, code R 18 553) is by R.A. Stokbroekx and colleagues with Janssen as senior author, so 'his hand plus his group' is the honest reading. Marketed as Imodium from 1973.

source

Photographs

Polish pharmacy pack of Loperamid WZF 2 mg tablets (Polfa Warszawa): purple-and-white carton of 30 with silver blister strips of small round white tablets.

Russian-market Imodium box of loperamide 2 mg orally disintegrating tablets, teal carton over a peel-open blister card; sold worldwide under the Imodium brand.

Xapkov ·CC BY-SA

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