Lofentanil

Chemistry

Also known as

• Lofentanilum
• Lofentanila
• 61380-40-3
• 7H7YQ564XV
• DTXSID201016402
• R-32792
• Lofentanilo
• (-)-METHYL CIS-3-METHYL-1-PHENETHYL-4-(N-PHENYLPROPIONAMIDO)ISONIPECOTATE

Stereoisomers

4 distinct stereoisomers are registered for this structure.

• Lofentanil this area CID 65499
• methyl (3R,4R)-3-methyl-1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxylate CID 6328619
• 3-Methyl-1-phenethyl-4-(phenyl-propionyl-amino)-piperidine-4-carboxylic acid methyl ester CID 10070040
• methyl (3S,4S)-3-methyl-1-(2-phenylethyl)-4-(N-propanoylanilino)piperidine-4-carboxylate CID 22795178
• Methyl 3-methyl-4-[(1-oxopropyl)phenylamino]-1-(2-phenylethyl)-4-piperidinecarboxylate mixture CID 123642

Attribution

• PJ

  Paul Janssen — first synthesis, 1976

  Janssen Pharmaceutica under his direction, from the same 1976 Van Bever/Janssen 4-anilinopiperidine series as carfentanil and sufentanil. Never marketed; year is the publication of the series, not necessarily the synthesis.

  source