Codeine: general
Codeine is an opiate used to treat mild to moderate pain and to suppress cough [1][2]. It's a natural alkaloid found in opium, making up a small percentage of the raw material [1], and is also produced by methylating morphine [3].
Codeine is a prodrug — your body has to convert it into morphine before it works, using a liver enzyme called CYP2D6 [1][4]. How much pain relief you get depends heavily on how active that enzyme is in you, and that activity varies genetically from person to person [5]. You likely don't know which kind of metabolizer you are.
Serious or life-threatening breathing problems are a known risk, particularly in the first day to three days of use [2].
Low-dose codeine (8 mg or less per tablet, 20 mg or less per 30 mL) is available from pharmacists without a prescription in some places [4].
Used at high doses over a long period, codeine is addictive [4].
References
- Codeine | C18H21NO3 | CID 5284371 — National Library of Medicine (PubChem)
- Codeine: MedlinePlus Drug Information — National Library of Medicine (MedlinePlus)
- Codeine (PIM 140) — IPCS INCHEM (World Health Organization)
- Codeine: Uses, effects and risks — Government of Canada
- Codeine - StatPearls — NCBI Bookshelf (StatPearls Publishing)
Comments
Sign in to join the conversation.
No comments yet.