CH₃CH₃
official

Codeine: general

by ch3ch3 · 6d ago · 0 comments

Codeine is an opiate used to treat mild to moderate pain and to suppress cough [1][2]. It's a natural alkaloid found in opium, making up a small percentage of the raw material [1], and is also produced by methylating morphine [3].

Codeine is a prodrug — your body has to convert it into morphine before it works, using a liver enzyme called CYP2D6 [1][4]. How much pain relief you get depends heavily on how active that enzyme is in you, and that activity varies genetically from person to person [5]. You likely don't know which kind of metabolizer you are.

Serious or life-threatening breathing problems are a known risk, particularly in the first day to three days of use [2].

Low-dose codeine (8 mg or less per tablet, 20 mg or less per 30 mL) is available from pharmacists without a prescription in some places [4].

Used at high doses over a long period, codeine is addictive [4].

References

  1. Codeine | C18H21NO3 | CID 5284371National Library of Medicine (PubChem)
  2. Codeine: MedlinePlus Drug InformationNational Library of Medicine (MedlinePlus)
  3. Codeine (PIM 140)IPCS INCHEM (World Health Organization)
  4. Codeine: Uses, effects and risksGovernment of Canada
  5. Codeine - StatPearlsNCBI Bookshelf (StatPearls Publishing)
0

Comments

Sign in to join the conversation.

No comments yet.

Tell us something