| Substance | Ohio | Federal |
|---|---|---|
| 7-OH (7-hydroxymitragynine) | Controlled substance (in effect since 2026-05-19) | pending: Temporary Placement of 7-Hydroxymitragynine Above a Specified Threshold in Schedule I |
| MGM-15 | Controlled substance (in effect since 2026-05-19) | Controlled substance (in effect since 2026-08-26) |
| Mitragynine pseudoindoxyl | Controlled substance (in effect since 2026-05-19) | Controlled substance (in effect since 2026-08-26) |
| Kratom (leaf and extracts) | Expressly excluded (in effect since 2026-05-19) | Restricted |
| Nitrous oxide (whippets, tanks) | not checked yet | Regulated; pending: H.R. 7945, Nitrous Oxide Safety Act of 2026 |
| Hemp THC and THCA | Restricted (in effect since 2026-03-20) | Regulated; pending: Public Law 119-103, division B, § 2019; restricted from 2026-12-11 |
| Tianeptine | not checked yet | pending: Schedules of Controlled Substances: Placement of Tianeptine in Schedule I |
| Phenibut | not checked yet | not checked yet |
| Poppers (alkyl nitrites) | not checked yet | Banned (in effect since 1991-02-27) |
| SR-17018 (5,6-dichloro desmethylchlorphine) | not checked yet | Controlled substance (in effect since 2026-08-27) |
The following are classified as schedule I controlled substances
hydroxymitragynine; mitragynine pseudoindoxyl; dihydro-7-hydroxy mitragynine
Ohio Adm.Code 4729:9-1-01.1, Mitragynine-Related Compounds (authenticated) Ohio Board of Pharmacy, Ohio Administrative Code
Our note: The rule covers synthetic and naturally occurring mitragynine-related compounds; it excludes natural leaf (see the kratom line).
The following are classified as schedule I controlled substances
mitragynine pseudoindoxyl; dihydro-7-hydroxy mitragynine; and 7-acetoxymitragynine
Ohio Adm.Code 4729:9-1-01.1, Mitragynine-Related Compounds (authenticated) Ohio Board of Pharmacy, Ohio Administrative Code
Our note: The rule names "dihydro-7-hydroxy mitragynine", which is MGM-15.
The following are classified as schedule I controlled substances
mitragynine pseudoindoxyl; dihydro-7-hydroxy mitragynine; and 7-acetoxymitragynine
Ohio Adm.Code 4729:9-1-01.1, Mitragynine-Related Compounds (authenticated) Ohio Board of Pharmacy, Ohio Administrative Code
Our note: The rule covers synthetic and naturally occurring mitragynine-related compounds; it excludes natural leaf (see the kratom line).
Mitragynine in vegetation form, including natural kratom leaf and ground natural kratom leaf
Ohio Adm.Code 4729:9-1-01.1, Mitragynine-Related Compounds (authenticated) Ohio Board of Pharmacy, Ohio Administrative Code
Our note: Leaf is excluded from the Schedule I rule; concentrated and synthetic mitragynine-related compounds are not. Food-safety law (Chapter 3715) still applies to leaf products.
Greater than four-tenths of a milligram combined total per container of total tetrahydrocannabinols, including tetrahydrocannabinolic acid
Ohio Revised Code 928.01, definitions (as amended by S.B. 56, 136th General Assembly) Ohio Legislative Service Commission, Ohio Laws
Our note: A final product above the cap is not "hemp" under Ohio law. The effective date is the one the Ohio Laws page shows for this section.