Ohio's rule placing 7-OH and related kratom compounds in Schedule I takes effect; plain kratom leaf is excluded

Ohio Administrative Code Rule 4729:9-1-01.1, classifying 7-hydroxymitragynine and related mitragynine compounds as Schedule I controlled substances, takes effect in Ohio on May 19, 2026.

The rule places mitragynine-related compounds in Schedule I [1], effective that date [1]. Named among those compounds are 7-hydroxymitragynine (7-OH), mitragynine pseudoindoxyl, dihydro-7-hydroxy mitragynine, and 7-acetoxymitragynine [1].

The rule also lists what the term "mitragynine-related compounds" does not cover [1]. Exclusion (D) covers mitragynine in vegetation form, including natural kratom leaf and ground natural kratom leaf, consistent with Chapter 3715 of the Ohio Revised Code [1]. In practical terms: plain kratom leaf and ground leaf material are not swept into this Schedule I classification. What changes is the legal status of the compounds named above. If you possess or use plain leaf or ground leaf kratom, this rule does not reclassify that product.

This is a state rule, not a federal one.

References

1. Ohio Administrative Code Rule 4729:9-1-01.1, Mitragynine-Related Compounds (authenticated) — Ohio Board of Pharmacy, Ohio Administrative Code (authenticated copy)