Missouri lists MGM-15, MGM-16, mitragynine pseudoindoxyl and SR-17018 in Schedule I; its attorney general calls high-7-OH products analogues

Missouri listed mitragynine pseudoindoxyl, MGM-15, MGM-16, SR-14968, SR-17018, cychlorphine and spirochlorphine as Schedule I controlled substances through an emergency rule effective September 25, 2026, and on October 15, 2026 the state attorney general announced new enforcement action against companies selling high-7-OH products, which her office says are Schedule I controlled substance analogues under Missouri law.

The emergency amendment to 19 CSR 30-1.002, filed September 11, 2026, effective September 25, 2026 and set to expire March 23, 2027, places mitragynine pseudoindoxyl, MGM-15, MGM-16, 5,6-dichloro brorphine (SR-14968), 5,6-dichloro desmethylchlorphine (SR-17018), N-propionitrile chlorphine (cychlorphine) and spirochlorphine on Missouri's temporary Schedule I list [1]. That listing is temporary: it expires March 23, 2027 [1], and a proposed amendment covering the same material was published in the October 15, 2026 issue of the Missouri Register [1].

7-hydroxymitragynine (7-OH) itself is not among the seven substances this emergency rule lists [1]. Separately, the Attorney General's office issued nine new civil investigative demands to nine companies [2] and cease-and-desist orders to KC Distro and Karmic Genesis demanding they stop selling 7-OH products immediately [2]. The office's stated position is that products with artificially elevated levels of 7-OH are Schedule I controlled substance analogues under Missouri law [2]; that stated position does not by itself add 7-OH to the list.

The release also states that mitragynine pseudoindoxyl and MGM-15 were added to Schedule I through an emergency DEA order on August 26, 2026, and that Missouri adopted that designation on September 25, 2026 [2].

The emergency rule is in force now; neither document gives a date by which the proposed amendment would be adopted.

References

1. Emergency amendment, 19 CSR 30-1.002 Schedules of Controlled Substances (Missouri Register Vol. 51, No. 20, pp. 1317-1325) — Missouri Department of Health and Senior Services, in the Missouri Register (Secretary of State)
2. Attorney General Hanaway Investigates Nine Additional Companies Over 7-OH Products (press release) — Missouri Attorney General's Office