| Substance | South Carolina | Federal |
|---|---|---|
| 7-OH (7-hydroxymitragynine) | not checked yet | pending: Temporary Placement of 7-Hydroxymitragynine Above a Specified Threshold in Schedule I |
| MGM-15 | not checked yet | Controlled substance (in effect since 2026-08-26) |
| Mitragynine pseudoindoxyl | not checked yet | Controlled substance (in effect since 2026-08-26) |
| Kratom (leaf and extracts) | not checked yet | Restricted |
| Nitrous oxide (whippets, tanks) | Banned (in effect since 2026-05-18) | Regulated; pending: H.R. 7945, Nitrous Oxide Safety Act of 2026 |
| Hemp THC and THCA | not checked yet | Regulated; pending: Public Law 119-103, division B, § 2019; restricted from 2026-12-11 |
| Tianeptine | not checked yet | pending: Schedules of Controlled Substances: Placement of Tianeptine in Schedule I |
| Phenibut | not checked yet | not checked yet |
| Poppers (alkyl nitrites) | not checked yet | Banned (in effect since 1991-02-27) |
| SR-17018 (5,6-dichloro desmethylchlorphine) | not checked yet | Controlled substance (in effect since 2026-08-27) |
Takes effect on the Governor's approval; the bill record shows the effective date 05/18/26.
A person may not possess, sell, market, or represent nitrous oxide for recreational inhalation.
This act takes effect upon approval by the Governor.
S. 751 (2026), Act No. 194, ratified text South Carolina Legislature
Our note: Banned for recreational inhalation, and flavoured nitrous products are banned outright. Home culinary cartridges of 8 grams or less are carved out.