Yuval Shvo
Yuval Shvo (also published as Youval Shvo) was an Israeli chemist who began in natural-product chemistry and spent most of his career at Tel Aviv University, where he was one of the founders of its organic chemistry teaching programme and where a teaching laboratory is named in his memory. In 1963 he and Raphael Mechoulam published "Hashish—I: The structure of cannabidiol", the paper that established the structure and stereochemistry of CBD, largely by then-new NMR methods; that structure was the basis on which the structure of Δ⁹-THC was worked out the following year. He did not continue in cannabinoid chemistry, and is not an author on the THC papers. In mainstream chemistry he is better known for the Shvo catalyst, a diruthenium complex reported in 1986 that hydrogenates and transfer-hydrogenates aldehydes, ketones and imines through cooperation between the metal and its ligand.
Compounds
1 credited across 1 class · 1 with a page here
- Phytocannabinoids
- CBD C21H30O2 isolated it, 1963 source
Second author with Raphael Mechoulam on "Hashish—I: The structure of cannabidiol", Tetrahedron 19:2073–2078 (1963), PMID 5879214, DOI 10.1016/0040-4020(63)85022-X. CBD had already been obtained in crystalline form in the early 1940s (Adams and co-workers); what the 1963 paper settled was its structure and stereochemistry, mostly by NMR. Mechoulam and Hanuš's 2000 review states this directly and notes the CBD structure was what the Δ⁹-THC structure was then built on. Shvo is not an author on the 1964 THC paper (Gaoni and Mechoulam) or the 1965 total synthesis, and should not be credited with THC.
Reading
- Hashish—I: The structure of cannabidiol (Tetrahedron, 1963) · paper
- A new group of ruthenium complexes: structure and catalysis (JACS, 1986) — the Shvo catalyst · paper
- Discovery, Applications, and Catalytic Mechanisms of Shvo's Catalyst (Chem. Rev., 2010) · paper
- A historical overview of chemical research on cannabinoids (Mechoulam & Hanuš, Chem. Phys. Lipids, 2000) · paper
- Shvo catalyst — Wikipedia · article
- In Memoriam, School of Chemistry, Tel Aviv University (Prof. Youval Shvo, 1930–2007) · obituary
- Youval Shvo — Wikidata (Q136312163) · archive